A bus rammed the woman in the center of town near Regent Street. The incident happened around 12:40 p.m. today, Monday.
Emergency services rushed to the scene on Margaret Street.
Despite their best efforts, the woman was pronounced dead at the scene.
This happened around 1 p.m.
After the crash, roads around the area were temporarily closed to keep pedestrians away from the scene.
Metropolitan Police officers were first called by the London Ambulance Service.
A Met spokesperson said: ‘Police were called by the London Ambulance Service at 12.42pm on Monday March 7 to a report of a bus colliding with a pedestrian on Margaret Street, W1.
“Officers and firefighters from London were present.
“Despite the efforts of the emergency services, the woman was pronounced dead at the scene at 1:13 p.m.
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A spokesperson said: ‘Firefighters attended a traffic collision involving a bus and a pedestrian.
“She was freed from under the vehicle by firefighters.
“She was unfortunately pronounced dead at the scene.
“The brigade was called at 12:42 p.m. and the incident was over for firefighters at 1:22 p.m..”
Reports suggest road closures remained in place as of 2:50 p.m.
Those affected included Piccadilly Circus and Oxford Street.